Gene tests may help predict outcomes in advanced ovarian cancer
21 March 2016, Nirapad News: A new genetic test might help gauge outcomes for women diagnosed with ovarian cancer, a new study suggests.
As researchers at the University of Washington in Seattle explained, advanced ovarian cancer doesn’t progress as rapidly in women who have mutations in certain “DNA repair” genes, known as homologous recombination genes. Women with the disease who also have these mutations may survive longer, said a team led by gynecologic oncologist Dr. Barbara Norquist.
The finding might also someday help guide treatment, the researchers said.
Experts said the findings highlight the increasing role of DNA tests in cancer care. There’s a “wealth of new information that is being generated with regard to the genetics of ovarian cancer, and this study shows how useful such information can be in the everyday management of patients,” said Dr. Mitchell Maiman, chair of obstetrics and gynecology at Staten Island University Hospital in New York City.
The new study came out of a phase 3 clinical drug trial involving Norquist’s team.
The researchers wondered if having mutations in DNA repair genes might affect a woman’s response to combination drug therapy for ovarian cancer.